Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function
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چکیده
منابع مشابه
Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways.
Bisphosphonates promote apoptosis of cancer cells as well as osteoclasts in bone metastatic sites, but several clinical trials and high concentration treatment have shown that bisphosphonates have side effects that include bone loss and damage to normal cells. The aim of this study was to elucidate the protective effect and the possible mechanism of activated protein C (APC) against bisphosphon...
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Protein C activation on the surface of the endothelium is critical to the negative regulation of blood coagulation. We now demonstrate that monoclonal antibodies that block protein C binding to the endothelial cell protein C receptor (EPCR) reduce protein C activation rates by the thrombin-thrombomodulin complex on endothelium, but that antibodies that bind to EPCR without blocking protein C bi...
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In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptoti...
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In vitro fertilization (IVF) is a well-documented risk factor for thromboembolic complications [1]. Hypercoagulability could be either intrinsic or may be induced by the hormonal treatment preceding the IVF procedure [2]. Possible plasma factor compositional reasons for the link between IVF and thrombotic events include activated protein C resistance [3]. Protein C regulates blood coagulation b...
متن کاملEndothelial Cell Protein C Receptor Gene 6936a/G, 1651c/G, 4678g/C Polymorphisms and Soluble Endothelial Protein C Receptor Levels Impact on in Vitro Fertilization Outcomes
In vitro fertilization (IVF) is a well-documented risk factor for thromboembolic complications [1]. Hypercoagulability could be either intrinsic or may be induced by the hormonal treatment preceding the IVF procedure [2]. Possible plasma factor compositional reasons for the link between IVF and thrombotic events include activated protein C resistance [3]. Protein C regulates blood coagulation b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.8.5447